The role of autophagy is generally understood to be securing nutrient sources through autodigestion in order to survive starvation conditions. However, in recent years, it has been found to work along with the proteasome system in the metabolism of cell components even in normal environments. Compared to proteasomes, which selectively degrade ubiquitinated proteins as their targets, in autophagy the space within the cell is entirely digested; therefore it is called a bulk degradation system. Recent researches and advances have shown an association of mammalian autophagy with diseases such as neurodegenerative disease, infection disease, cardiac disease as well as cancers.
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