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HOME > Product search results > Code No. D204-5
Anti-CD52 (CAMPATH-1) (Mouse) mAb-PE
Code No. D204-5
Anti-CD52 (CAMPATH-1) (Mouse) mAb-PE
Size
1 mL (50 tests)
Data Sheet| Clonality | Monoclonal | Clone | BTG-2G | ||
|---|---|---|---|---|---|
| Isotype (Immunized Animal) | Rat IgG2aκ | ||||
| Immunogen (Antigen) | mouse IL-2Rα-transgenic mice splenocyte | ||||
| Storage buffer | PBS/1% BSA/0.09% NaN3 | ||||
| Storage temp. | 4°C | ||||
| Alternative names | B7, MB7, CLS1, B7-Ag | ||||
| Background | CAMPATH-1, also known as CD52, is a heavily glycosylated, GPI-anchored protein expressed at high levels on almost all thymocytes, lymphocytes, monocytes, and macrophages. CAMPATH-1 is an exceptionally good target for complement-mediated cell lysis and antibody-mediated cellular cytotoxicity. Humanized CAMPATH-1 antibodies have been used therapeutically to effectively deplete lymphocytes in allogeneic bone marrow transplants, hematologic malignancies, and autoimmune diseases. Clinical trials suggest CAMPATH-1 antibodies are especially promising in the treatment of leukemia, non-Hodgkin lymphomas, and rheumatoid arthritis. The apparent size of CAMPATH-1 by SDS-PAGE is 25-29 kDa; however, the actual molecule is much smaller, ~ 8-9 kDa as confirmed by total structure analysis and mass spectrometry. | ||||
- The availability is based on the information in Japan at 00:05, Sep 15, 2024 in JST.
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- Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation - For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
- For storage temparature: RT: room temparature
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