Code No. | Product name | Synonyms | Reactivity | Applications | Function, localization |
---|---|---|---|---|---|
RN032P | Anti-CIRBP pAb | CIRP | Hu/ Mo/ Rat | WB/ IP/ RIP | CIRBP is involved in cold stress-induced suppression of cell proliferation. It also serves as a translational activator to promote the translation of mRNA under mild hypothermic conditions. |
RN035PW | Anti-CUGBP2 pAb | CELF2 | Hu/ Mo/ Rat/ Ham | WB | CUGBP2 is highly expressed in most tissues including muscle. It is involved in stabilization of COX2 mRNA via binding to 3'-UTR of the mRNA. It also induces apoptosis in tumor cells via binding to 3'-UTR of Mcl-1 mRNA. |
RN063PW | Anti-DHX9 pAb | NDHII, RHA | Hu/ Mo/ Ham | WB/ IP | DHX9 is an RNA helicase that shuttles between nucleus and cytoplasm. DHX9 is involved in stabilization of c-myc mRNA via asscoation with IMP1, HNRNPU, YBX1and SYNCRIP. |
RN003M | Anti-EIF2C2 (AGO2) (Human) mAb | AGO2 | Hu | WB/ IP/ RIP | AGO2, a core component of RNA-induced silencing complex (RISC), plays a central role in RNAi pathway. It is reported that AGO2 is localized to P-bodies and involved in mRNA decay. |
RN001P | Anti-EIF4E pAb | Hu/ Mo/ Rat/ Ham | WB/ IP/ RIP/ IC/ IF | EIF4E, one of the translation-intiation factors, binds to m7G cap structure of eukaryotic mRNA. It is also related to mRNA export from nucleus to cytoplasm. | |
RN006M | Anti-EIF4E mAb | Hu/ Mo/ Rat/ Ham | WB/ IP/ RIP | EIF4E, one of the translation-intiation factor, binds to m7G cap structure of eukaryotic mRNA. It is also related to export of mRNA from nucleus to cytoplasm. | |
RN004P | Anti-ELAVL1 (HuR) pAb | HuR | Hu/ Mo/ Rat/ Ham | WB/ IP/ RIP/ IC/ IF | ELAVL1/HuR, a ubiquitously expressed protein, binds to both poly(A) and AU-rich element of mRNA. It is reported that HuR regulates mRNA export via shuttling between nucleus and cytoplasm. |
RN007M | Anti-ELAVL1 (HuR) mAb | HuR | Hu/ Mo/ Rat/ Ham | WB/ IP/ RIP | ELAVL1/HuR, a ubiquitously expressed protein, binds to both poly(A) and AU-rich element of mRNA. It is reported that HuR regulates mRNA export via shuttling between nucleus and cytoplasm. |
RN005P | Anti-ELAVL2 (HuB) (Human) pAb | HuB | Hu | WB/ IP/ RIP/ IC/ IF | ELAVL2/HuB, one of Hu family proteins, is specifically expressed in neuronal cells. It shuttles between nucleus and cytoplasm and regulates stabilization and translational efficiency of mRNAs via binding to AU-rich elements of them. |
RN006P | Anti-ELAVL3 (HuC) pAb | HuC | Hu/ Mo/ Rat | WB/ IP/ RIP | ELAVL3/HuC, a member of Hu protein family, may be related to neuronal development. It shuttles between nucleus and cytoplasm and regulates stability and translational efficiency of mRNAs via binding to AU-rich elements of them. |
RN048PW | Anti-G3BP1 pAb | G3BP | Hu | WB/ IP | G3BP1, a DNA/RNA helicase, is involved in stress granule formation. It also promotes mRNA decay by binding to 3'-UTR in c-Myc mRNA and stabilization of Tau mRNA. |
RN125PW | Anti-HENMT1 pAb | HEN1, C1orf59 | Hu/ Mo/ Rat | WB | HENMT1, small RNA 2'-O-methyltransferase, mediates stabilization of piRNA by adding 2'-O-methyl group to the 3'-end of mammalian piRNAs. HENMT1 is preferentially expressed in testis and required for mouse spermatogenesis. |
RN114PW | Anti-HNRNPA1 pAb | Hu/ Mo/ Rat/ Ham(w) | WB/ IP | HNRNPA1 is a multi-functional DNA/RNA binding protein involved in transcription, pre-mRNA splicing, stability, translation and miRNA biogenesis. HNRNPA1 stabilizes IL2 and GM-CSF mRNA by binding to AU-rich elements in their 3'-UTR. | |
RN052PW | Anti-HNRNPC pAb | Hu/ Mo | WB/ IP | HNRNPC binds and stabilizes APP mRNA. It also promotes translation of APP mRNA via binding to the coding region of the mRNA in competition with FMR1. | |
RN060PW | Anti-HNRNPD (AUF1) pAb | AUF1 | Hu/ Mo/ Rat/ Ham | WB/ IP | HNRNPD regulates mRNA decay by binding to AU-rich element in the mRNA. It is also involved in translation-dependent mRNA degradation through interaction with EIF4G1 and PABP. |
RN007P | Anti-IGF2BP1 (IMP1) pAb | ZBP1 | Hu/ Mo | WB/ IP/ RIP/ IC/ IF | IGF2BP1 (IMP1) is involved in stabilization of c-myc mRNA via asscoation with HNRNPU, YBX1, DHX9 and SYNCRIP. |
RN001M | Anti-IGF2BP1 (IMP1) mAb | ZBP1 | Hu/ Mo | WB/ IP/ RIP | IGF2BP1 (IMP1) is involved in stabilization of c-myc mRNA via asscoation with HNRNPU, YBX1, DHX9 and SYNCRIP. |
RN127PW | Anti-NSUN2 (Human) pAb | MISU, MRT5, SAKI, TRM4 | Hu | WB/ IP | NSUN2, identified as tRNA m5C methyltransferase, catalyzes the conversion of cytidine to m5C in tRNAs, mRNA and miRNA. m5C RNA modifications by NSUN2 affects mRNA stability, translation regulation and miRNA biogenesis. |
RN009M | Anti-PABPC1 mAb | PABP1 | Hu/ Ham | WB/ IP/ RIP/ IC | PABPC1 functions as a stabilizer of mRNA by binding to its poly(A) tail. PABPC1 is involved in deadenylation and degradation of its mRNA after translation termination. It has also been reported that PABPC1 plays an important role in NMD. |
RN023PW | Anti-PABPN1 pAb | PABP2 | Hu/ Mo | WB/ IP | PABPN1, localized to nucleus, strongly binds to poly(A) of primary mRNA after transcription. It is important to regulate the length of poly(A) tail by polyadenylation and associated with mRNA maturation. |
RN024P | Anti-PCBP1 pAb | HNRPE1 | Hu/ Mo/ Rat | WB/ IP/ RIP | PCBP1 is one of the major PCBP isoforms shuttling between nucleus and cytoplasm. It stabilizes target mRNAs such as α-globin and type I collagen via binding to poly(rC) and polypyrimidine. |
RN025P | Anti-PCBP2 pAb | HNRPE2 | Hu/ Mo/ Rat | WB/ IP/ RIP | PCBP2 binds to poly(rC) in the same way as PCBP1 and hnRNPK, and has been reported to bind to poly(rU) as well. It is localized in stress granule and P-body. |
RN011P | Anti-PTBP1 (Human) pAb | hnRNPI | Hu | WB/ IP/ RIP/ IF* | PTBP1 regulates the stability of mRNA such as CD40LG. It is also involved in exon inclusion in competition with other splicing repressors. |
RN012P | Anti-STAU1 (Human) pAb | Hu | WB/ IP/ RIP | STAU1 is a key molecule in Staufen-Mediated Decay (SMD). STAU1 recruits UFP1, an essential player of Nonsense-Mediated Decay (NMD), via binding to cis-element in the 3'-UTR of target mRNA and regulates the mRNA decay. | |
RN107PW | Anti-TARDBP (TDP-43) pAb | TDP-43 | Hu/ Mo/ Ham | WB/ IP | TARDBP (TDP-43) is a nuclear DNA/RNA binding protein involved in mRNA splicing, nuclear export, stability, miRNA biogenesis and transcriptional repression. TARDBP is mainly localized in nucleus, but in cytoplasm in neurodegenerative diseases such as ALS. |
RN033P | Anti-TNRC6A (GW182) pAb | GW182, GW1 | Hu/ Mo/ Rat | WB/ IP/ RIP/ IC* | TNRC6A/GW182, associated with gene silencing by small ncRNA such as miRNA, has RNA recognition motif and several AGO binding domains. TNRC6A serves as a trasnlational repressor of mRNA via binding to RISC components. It is reported that TNRC6A is a major component of P-body/GW-body. |
RN123PW | Anti-YTHDF2 pAb | CAHL, HGRG8, NY-REN-2 | Hu/ Mo/ Rat(w)/ Ham | WB/ IP | YTHDF2, functioning as m6A reader protein, is involved in methylation-dependent RNA decay. Binding of YTHDF2 to m6A containing mRNAs leads to localization of the mRNAs to P-body and degradation. |
For applications: *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.