Products may not be approved for sale as in vitro diagnostics in all countries.
Please contact us for further details.
Customers in the US, please contact MBL International Corporation for details. ⇒
|Anti-Integrin αvβ6 ELISA Kit||5288||96 wells||ELISA|
: Research Use Only Reagent
The anti-integrin αvβ6 antibody is an autoantibody against integrin αvβ6. Integrin is a cell-surface receptor that is responsible for cell adhesion by binding to the extracellular matrix, and it has a heterodimer structure, with two subunits, α and β, that are non-covalently bound together. In mammals, there are 24 different types of integrin, among which integrin αvβ6 is expressed exclusively by epithelial cells, and functions as a receptor of fibronectin and other extracellular matrix proteins. Integrin αvβ6 expressed by the intestinal epithelium is associated with suppression of inflammation, and prevention of infection by pathogens and parasites(1). Anti-integrin αvβ6 antibody is frequently detected in ulcerative colitis (UC) patients(2, 3), and its antibody titer has been reported to be correlated with disease activity(2).
- Koivisto L, Bi J, Häkkinen L, Larjava H. Integrin αvβ6: Structure, function and role in health and disease. Int J Biochem Cell Biol. 2018;99:186-96.
- Kuwada T, Shiokawa M, Kodama Y, Ota S, Kakiuchi N, Nannya Y, et al. Identification of an Anti-Integrin αvβ6 Autoantibody in Patients With Ulcerative Colitis. Gastroenterology. 2021;160(7):2383-94.e21.
- Uzzan M, Martin JC, Mesin L, Livanos AE, Castro-Dopico T, Huang R, et al. Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity. Nat Med. 2022.