Ulcerative Colitis

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Product Code No. Size Method RUO/IVD/
CE-IVD		 IFU SDS
Anti-Integrin αvβ6 ELISA Kit 5288 96 wells ELISA RUOアイコン

RUOアイコン : Research Use Only Reagent

The anti-integrin αvβ6 antibody is an autoantibody against integrin αvβ6. Integrin is a cell-surface receptor that is responsible for cell adhesion by binding to the extracellular matrix, and it has a heterodimer structure, with two subunits, α and β, that are non-covalently bound together. In mammals, there are 24 different types of integrin, among which integrin αvβ6 is expressed exclusively by epithelial cells, and functions as a receptor of fibronectin and other extracellular matrix proteins. Integrin αvβ6 expressed by the intestinal epithelium is associated with suppression of inflammation, and prevention of infection by pathogens and parasites1). Anti-integrin αvβ6 antibody is frequently detected in ulcerative colitis (UC) patients2,3), and its antibody titer has been reported to be correlated with disease activity2).


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Anti-integrin αvβ6 autoantibody


References

  1. Koivisto L, Bi J, Häkkinen L, Larjava H. Integrin αvβ6: Structure, function and role in health and disease. Int J Biochem Cell Biol. 2018;99:186-96.
  2. Kuwada T, Shiokawa M, Kodama Y, Ota S, Kakiuchi N, Nannya Y, et al. Identification of an Anti-Integrin αvβ6 Autoantibody in Patients With Ulcerative Colitis. Gastroenterology. 2021;160(7):2383-94.e21.
  3. Uzzan M, Martin JC, Mesin L, Livanos AE, Castro-Dopico T, Huang R, et al. Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity. Nat Med. 2022.