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Product Code No. Volume Method RUO/IVD/
HEXAMATE Factor XIII 04942354R R1 (Reaction buffer):
2 x 2.3 mL
R2 (Latex reagent):
2 x 2.9 mL
CE-IVDアイコン eIFUアイコン SDSアイコン
HEXAMATE Factor XIII – Calibrator 04942362R 3 x 1.0 mL  ー CE-IVDアイコン eIFUアイコン SDSアイコン
HEXAMATE Factor XIII – Control I/II 04942371R Control I: 3 x 1.0 mL
Control II: 3 x 1.0 mL
 ー CE-IVDアイコン eIFUアイコン SDSアイコン

CE-IVDアイコン : CE-marked In vitro Diagnostic Reagent

HEXAMATE Factor XIII is used for quantitative measurement of Factor XIII (FXIII) in plasma with HEXAMATE Factor XIII – Calibrator and HEXAMATE Factor XIII – Control I/II.
FXIII is present in plasma, platelets, erythrocytes and other cells. FXIII is a proenzyme, protransglutaminase, which circulates in an inactive form as a heterotetramer consisting of two catalytic A subunits and two carrier/protective B subunits (FXIII-A2B2). The activated FXIII (cleaved FXIII-A2) undergoes conformational changes exposing active-site cysteine residues, which react with fibrin monomers catalyzing their cross-linking.
Congenital FXIII deficiency causes diseases mainly associated with bleeding tendency, such as umbilical cord bleeding hemorrhage, impaired wound healing failure, and severe deep bleeding, while acquired Factor XIII deficiency is observed in disseminated intravascular coagulation (DIC), severe liver disorders, malignant tumors, and leukemia. The FXIII measurement is an aid in the diagnosis of these diseases.