Coagulation
Products may not be approved for sale as in vitro diagnostics in all countries.
Please contact us for further details.
Customers in the US, please contact MBL International Corporation for details. 
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| Product | Code No. | Volume | Method | RUO/IVD/ CE-IVD |
IFU | SDS |
|---|---|---|---|---|---|---|
| HEXAMATE Factor XIII | 04942354R | R1 (Reaction buffer): 2 x 2.3 mL R2 (Latex reagent): 2 x 2.9 mL |
latex turbidimetry |
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| HEXAMATE Factor XIII – Calibrator | 04942362R | 3 x 1.0 mL | ー | |
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| HEXAMATE Factor XIII – Control I/II | 04942371R | Control I: 3 x 1.0 mL Control II: 3 x 1.0 mL |
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: CE-marked In vitro Diagnostic Reagent
HEXAMATE Factor XIII is used for quantitative measurement of Factor XIII (FXIII) in plasma with HEXAMATE Factor XIII – Calibrator and HEXAMATE Factor XIII – Control I/II.
FXIII is present in plasma, platelets, erythrocytes and other cells. FXIII is a proenzyme, protransglutaminase, which circulates in an inactive form as a heterotetramer consisting of two catalytic A subunits and two carrier/protective B subunits (FXIII-A2B2). The activated FXIII (cleaved FXIII-A2) undergoes conformational changes exposing active-site cysteine residues, which react with fibrin monomers catalyzing their cross-linking.
Congenital FXIII deficiency causes diseases mainly associated with bleeding tendency, such as umbilical cord bleeding hemorrhage, impaired wound healing failure, and severe deep bleeding, while acquired Factor XIII deficiency is observed in disseminated intravascular coagulation (DIC), severe liver disorders, malignant tumors, and leukemia. The FXIII measurement is an aid in the diagnosis of these diseases.