▼This Kit is used in the following research paper！
Kobayashi, H. et al. ; A new rapid acetylcholinesterase staining kit for diagnosing Hirschsprung's disease. Pediatr Surg Int. 23, 505-508 (2007)
Acetylcholinesterase (AChE) is a tetrameric serine hydrolase that rapidly catalyzes the hydrolysis of acetylcholine to acetate and choline.
The breakdown of acetylcholine is critical for the termination of impulse transmissions at cholinergic synapses within the nervous system. Progressive loss of cholinergic neurons in Alzheimer's disease (AD) patients results in severe memory loss and impairment of cognitive function. AChE inhibitors are a strategic approach to symptomatic treatment for AD, since AChE inhibitors increase the levels of acetylcholine in the synapse, thereby enhancing cholinergic activity in the affected regions of the brain.
AChE also plays an important role in agriculture since
modifications in AChE can confer resistance to pesticides.
AChE is a key component in many snake venoms, and
AChE staining is routinely used for the initial diagnosis of
Hirschsprung's disease, a congenital disorder caused by the
absence of ganglion cells in the distal colon.
Myenteric ganglia in normal intestine (x 200)
Submucosal hypertrophic nerve trunks in Hirschsprung's disease (x 400)
The photos are provided by Dr. Kobayashi Hiroyuki, Department of Pediatric Surgery, Juntendo University School of Medicine.
Staining procedure is easy and quick !
＊Please refer to the data sheet for detailed procedure.
|Code No.||Product||Size||Price (Tax excluded)|
|8450||Acetylcholinesterase Rapid Staining Kit||30 tests||￥40,000|
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