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Tyrosine Kinase Assay Kits




Histone The tyrosine kinases are divided into two main families: the receptor tyrosine kinase (RTK) and cytoplasmic protein (Non-receptor tyrosine kinase). Receptor tyrosine kinases (RTK)s are the high-affinity cell surface receptors for many growth factors, cytokines, and hormones. Both families play critical roles in a variety of cellular signal transduction pathways, regulating such diverse processes as cell division, adhesion, angiogenesis, and survival. These also have a main role in the development and progression of many types of cancer.


Met Kinase Assay/Inhibitor Screening Kit

 

CycLex Met Kinase Assay/Inhibitor Screening Kit is designed to measure the activities of recombinant catalytic domain of Met for the rapid and sensitive evaluation of inhibitors or activators.
Met is involved in malignant cell transformation. Increased Met expression has been found in a significant percentage of human cancers and is amplified during the transition between primary tumors and metastasis. Dysregulation of Met activity in cells is thought to be a key event underlying tumor metastasis, and indeed, Met overexpression and hyperactivation are reported to correlate with metastatic ability of the tumor cells.

Met Kinase Assay/Inhibitor Screening Kit 

Pyk2 Kinase Assay/Inhibitor Screening Kit

 

CycLex Pyk2 Kinase Assay/Inhibitor Screening Kit is designed to measure the activities of recombinant catalytic domain of Pyk2 (Prolinerich Tyrosine Kinase 2) for the rapid and sensitive evaluation of inhibitors or activators.
The focal adhesion PTK family consists of the focal adhesion kinase (FAK) and the Pyk2 kinase (also known as RAFTK, CAK-beta and CADTK). Pyk2 kinase can be activated in response to various stimuli, such as TNF-alpha, changes in osmolarity, elevation in intracellular calcium concentration, lysophosphatidic acid, in addition of bradykinin, a neuropeptide hormone that binds to a G protein-coupled receptor and in turn stimulates phosphatidylinositol hydrolysis.

Pyk2 Kinase Assay/Inhibitor Screening Kit 

c-Src Kinase Assay/Inhibitor Screening Kit

 

CycLex c-Src Kinase Assay/Inhibitor Screening Kit is designed to measure the activities of recombinant catalytic domain of c-Src for the rapid and sensitive evaluation of inhibitors or activators.
The Src family of non-receptor protein tyrosine kinases plays critical roles in a variety of cellular signal transduction pathways, regulating such diverse processes as cell division, motility, adhesion, angiogenesis, and survival. Constitutively activated variants of Src family kinases, including the viral oncoproteins v-Src and v-Yes, are capable of inducing malignant transformation of a variety of cell types. Src family kinases, most notably although not exclusively Src, are frequently overexpressed and/or aberrantly activated in a variety of epithelial and non-epithelial cancers.

c-Src Kinase Assay/Inhibitor Screening Kit 

p56Lck Kinase Assay/Inhibitor Screening Kit

 

CycLex p56Lck Kinase Assay/Inhibitor Screening Kit is designed to measure the activities of recombinant catalytic domain of Lck for the rapid and sensitive evaluation of inhibitors or activators.
Lck is a 56-kDa protein tyrosine kinase that is predominantly expressed in T lymphocytes. A member of the Src kinase family, it has a unique N-terminal region followed by SH3, SH2, and catalytic domains. Lck is an important protein tyrosine kinase in lymphocytes. Its overexpression renders T cells hypersensitive to antigen stimulation, and an Lckdeficient T cell line exhibits dramatically reduced protein tyrosine phosphorylation following T cell receptor (TCR) cross-linking.

p56Lck Kinase Assay/Inhibitor Screening Kit 

TrkA Kinase Assay/Inhibitor Screening Kit

 

CycLex TrkA Kinase Assay/Inhibitor Screening Kit is designed to measure the activities of recombinant catalytic domain of TrkA for the rapid and sensitive evaluation of inhibitors or activators.
The Trk (tropomyosin receptor kinase) receptors belong to the family of receptor tyrosine kinases, and three trk genes have been identified in mammals. The TrkA protooncogene was first identified as an nerve growth factor receptor (NGFR), followed by TrkB and TrkC. Nerve growth factor (NGF) is the preferred ligand for TrkA, brain-derived neurotrophic factor (BDNF) and Neurotrophin-4/5 (NT-4/5) are preferred for TrkB, and Neurotrophin-3 (NT-3) for TrkC. These specificities are not absolute, and NT-3 is also a ligand for TrkA and TrkB.

TrkA Kinase Assay/Inhibitor Screening Kit