Availability (in Japan)
0
(Contact us)
(In Japan at 17:00,
Feb 7, 2025 in JST)
Size
100 µg
Only available for the customers in Singapore, Taiwan and South Korea
Storage and Stability:Storage temp. | -80°C | Manufacturer | ImmunoPrecise Antibodies (Europe) BV | ||
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Alternative names | Somatotropin, Pituitary growth hormone, growth hormone 1 | ||||
Background | Product description: Human growth hormone is a plasma protein with a calculated molecular weight of 22.1 kDa. The protein is a member of the somatotropin/prolactin family of hormones, which play an important role in growth control. Its gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. This protein is the product of all five exons. The gene of human growth hormone was cloned, the protein was over-expressed in HEK293EBNA1 cells and was purified to homogeneity. The calculated molecular weight is 23.1 kDa and it contains an C-terminal hexahistidine tag. Reference sequences: Swiss-prot P01241 |
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