Antibody detailed product information

Code No. W357-3 プリントPrint out
Anti-CD105 (Endoglin) (Human) mAb
Size 100 µg/100 µL
Availability (in Japan) 10 or more
(In Japan at 17:00, Dec 2, 2021 in JST)
Clonality Monoclonal
Clone 3G4A6
Isotype
(Immunized Animal)
Mouse IgG2bκ
Applications FCM 1-10 µg/mL  
Immunogen
(Antigen)
Human CD105 (Endoglin) expressed Ba/F3 transfectants generated from SST-REX (signal sequence trap by retrovirus-mediated expression screening).
Reactivity [Gene ID]

Human[2022]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C
Conjugate Unlabeled
Manufacturer MBL
Alternative names END, HHT1, ORW1
Background Endoglin, also known as CD105, is a type I membrane protein. Endoglin is a major glycoprotein located on the cell surface of vascular endothelium. It is involved in regulation of angiogenesis. In cancer tissue, endoglin is over-expressed in proliferating endothelial cells which line tumor blood vessels. Moreover, tumor cells also express endoglin in prostate cancer and melanoma. Endoglin might be a good candidate to be used for tumor imaging and for targeted cancer therapy.
Related products W164-3 Anti-RHBDD3 (Human) mAb
M077-3 Mouse IgG2b (isotype control)
MTG-001 Clear Back (Human Fc receptor blocking reagent)
Product category Research area:Cancer
Tools:Flow cytometry reagents
Data

References
  1. Kojima T, Kitamura T. A signal sequence trap based on a constitutively active cytokine receptor. Nat Biotechnol. 17, 487-90 (1999)
  2. Castonguay R et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 286, 30034-46 (2011)
  3. Chen Y et al. Soluble endoglin modulates aberrant cerebral vascular remodeling. Ann Neurol. 66, 19-27 (2009)
  4. Lee NY et al. Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC. J Biol Chem. 283, 32527-33 (2008)
  5. Bellón T et al. Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions. Eur J Immunol. 23, 2340-5 (1993)
  • The availability is based on the information in Japan at 17:00, Dec 2, 2021 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.
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