Code No. | RN019P | Print out |
Anti-HNRNPK pAb | ||
Size | 200 µL (1 mg/mL) | |
Availability (in Japan) | 1-9
(In Japan at 00:05, Mar 29, 2024 in JST) |
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Clonality | Polyclonal | |
Clone | Polyclonal | |
Isotype (Immunized Animal) |
Rabbit Ig (aff.) | |
Applications | WB 1 µg/mL IP 5 µg/500 µL of cell extract from 5 x 106 cells IC* reported. (PMID: 24990929 / 26990993) RIP 15 µg/500 µL of cell extract from 1.5 x 107 cells Other(eCLIP) reported. (PMID: 27018577) |
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Immunogen (Antigen) |
KLH conjugated synthetic peptide, corresponding to C-terminus of human HNRNPK | |
Reactivity [Gene ID] | ||
Storage buffer | 1 mg/mL in PBS/50% glycerol, pH 7.2 | |
Storage temp. | -20°C | |
Conjugate | Unlabeled | |
Manufacturer | MBL | |
Alternative names | heterogeneous nuclear ribonucleoprotein K, RP11-575L7.1, CSBP, HNRPK, TUNP | |
Background | The heterogeneous nuclear ribonucleoprotein K (hnRNP K), is an RNA-binding protein containing 3 KH RNA-binding domains. It binds to both RNA and DNA and is a component of the hnRNP complex. hnRNP K is associated with pre-mRNA and appears to influence the processing of pre-mRNAs and metabolism of mRNA. hnRNP K is predominantly localized at the nucleus and shuttles between the nucleus and the cytoplasm. Therefore, hnRNP K is thought to be involved in the transport of mRNA. Phosphorylation of hnRNP K leads to its cytoplasmic accumulation and is important for cell migration and metastasis. In the cytoplasm, hnRNP K functions as a translational regulator of specific mRNAs such as c-myc mRNA, 16L2 mRNA, and r15-LOX mRNA. Further, it specifically associates with c-src kinase, leading to c-src activation and hnRNP K phosphorylation, which affect the binding of hnRNP K to RNA. | |
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Product category | Research area:RNA-RNP Network Brands:RiboCluster Profiler™ |
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Data | ||
Citations | Western Blotting
Immunoprecipitation
Immunocytochemistry
RNP Immunoprecipitation
Other(eCLIP)
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