Antibody detailed product information

Code No.	PM096
Anti-PER2 (Human) pAb
Size	50 µL
Availability (in Japan)	10 or more （In Japan at 17:00, Apr 16, 2024 in JST）
Clonality	Polyclonal
Clone	Polyclonal
Isotype (Immunized Animal)	Guinea pig Ig (aff.)
Applications	WB　1:500 IP　2 µL/sample
Reactivity [Gene ID]	Human[8864], Mouse(-)[18627]
Storage buffer	TBS/50% glycerol, pH 7.5
Storage temp.	-20°C
Conjugate	Unlabeled
Manufacturer	MBL
Alternative names	period circadian clock 2, FASPS, FASPS1, period2
Background	The circadian clock is a 24-hour endogenous oscillator, which cycles via transcriptional/translational feedback loops of clock genes and their products in individual cells. CLOCK and BMAL1 are positive factors in the loop, and their complex binds to E-box elements of Period (PER) and Cryptochrome (CRY) genes. In turn, this E-box-dependent transactivation is suppressed by binding of PER and CRY proteins to the CLOCK-BMAL1 complex. Gene polymorphisms of PER2 are also associated with improper cell division, cancer development, improper alcohol intake, and familial advanced sleep-phase syndrome (FASPS).
Related products	D335-3 Anti-BMAL1 mAb D334-3 Anti-CLOCK (Mouse) mAb D333-3 Anti-CLOCK (Mouse) mAb PM075 Anti-GNAT2 (Zebrafish) pAb PM079 Anti-DBP (Mouse) pAb D349-3 Anti-CLOCK mAb PM081 Anti-Cry1 (Mouse) pAb PM082 Anti-Cry2 (Mouse) pAb PM083 Anti-Per2 (Mouse) pAb PM087 Anti-Chrono (Mouse) pAb PM091 Anti-Per1 (Mouse) pAb PM092 Anti-NR1D1 (Rev-erbα) pAb PM093 Anti-NR1D2 (Rev-erbβ) pAb PM097 Anti-NFIL3 (E4BP4) pAb M225-3 Anti-NFIL3 (E4BP4) chimeric mAb PM067 Normal Guinea Pig IgG CY-1173 CycLex^® CaM-kinase II Assay Kit
Product category	Research area:Circadian rhythm Signal transduction
Data
References	Zheng B et al. Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. Cell 105, 683-94 (2001)（PMID: 11389837） Bae K et al. Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Neuron 30, 525-36 (2001)（PMID: 11395012） Lee Y et al. Stoichiometric relationship among clock proteins determines robustness of circadian rhythms. J Biol Chem. 286, 7033-42 (2011)（PMID: 21199878） Siepka SM et al. Genetics and Neurobiology of Circadian Clocks in Mammals. Cold Spring Harb Symp Quant Biol 72, 251-259 (2007)（PMID: 18419282） Ko CH, Takahashi JS. Molecular components of the mammalian circadian clock. Hum. Mol. Genet. 15, R271-7 (2006)（PMID: 16987893） Camacho F et al. Human casein kinase Idelta phosphorylation of human circadian clock proteins period 1 and 2. FEBS Lett. 489, 159–165 (2001)（PMID: 11165242）

The availability is based on the information in Japan at 17:00, Apr 16, 2024 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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