Antibody detailed product information

Code No.	M220-3
Anti-HB-EGF mAb
Size	100 µL (1 mg/mL)
Availability (in Japan)	1-9 （In Japan at 00:05, Apr 20, 2024 in JST）
Clonality	Monoclonal
Clone	2-108
Isotype (Immunized Animal)	Mouse IgG1 κ
Applications	WB　1 µg/mL （PMID: 26974561） IP*　reported. （PMID: 26974561） IC*　reported. （PMID: 26974561） IH　1 µg/mL ELISA*　reported. （PMID: 26974561）
Immunogen (Antigen)	extracellular region of HB-EGF
Reactivity [Gene ID]	Human[1839], Mouse(-)(PMID: 26974561), Rat**
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C
Conjugate	Unlabeled
Manufacturer	MBL
Alternative names	proheparin-binding EGF-like growth factor, Heparin-binding EGF-like growth factor, Diphtheria toxin receptor
Background	Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family that bind to and activate the EGF receptor (EGFR/ErbB1) and ErbB4. HB-EGF is synthesized as a single pass membrane-anchored precursor containing a heparin-binding domain, EGF domain, and cytoplasmic domain and then released in the soluble form by ectodomain shedding. HB-EGF is necessary for normal development of the lung, eyelid, and heart and also plays important roles in the development and progression of cancer, such as in cancer metastasis and angiogenesis, and drug-resistance.
Related products	D308-3 Anti-HB-EGF (Human) mAb MI-12-1 Anti-EGF-R (Human) mAb
Product category	Research area:Cancer
Data
Citations	Western Blotting Iwamoto R et al. Characterization of a Novel Anti-Human HB-EGF Monoclonal Antibody Applicable for Paraffin-Embedded Tissues and Diagnosis of HB-EGF-Related Cancers. Monoclon Anti Immunodiagn Immunother. 35, 73-82 (2016) Monoclon Antib Immunodiagn Immunother. 35, 73-82 (2016)(PMID:26974561) Immunoprecipitation Iwamoto R et al. Characterization of a Novel Anti-Human HB-EGF Monoclonal Antibody Applicable for Paraffin-Embedded Tissues and Diagnosis of HB-EGF-Related Cancers. Monoclon Anti Immunodiagn Immunother. 35, 73-82 (2016) Monoclon Antib Immunodiagn Immunother. 35, 73-82 (2016)(PMID:26974561) Immunocytochemistry Iwamoto R et al. Characterization of a Novel Anti-Human HB-EGF Monoclonal Antibody Applicable for Paraffin-Embedded Tissues and Diagnosis of HB-EGF-Related Cancers. Monoclon Anti Immunodiagn Immunother. 35, 73-82 (2016) Monoclon Antib Immunodiagn Immunother. 35, 73-82 (2016)(PMID:26974561) Immunohistochemistry Iwamoto R et al. Characterization of a Novel Anti-Human HB-EGF Monoclonal Antibody Applicable for Paraffin-Embedded Tissues and Diagnosis of HB-EGF-Related Cancers. Monoclon Anti Immunodiagn Immunother. 35, 73-82 (2016) Monoclon Antib Immunodiagn Immunother. 35, 73-82 (2016)(PMID:26974561) ELISA Iwamoto R et al. Characterization of a Novel Anti-Human HB-EGF Monoclonal Antibody Applicable for Paraffin-Embedded Tissues and Diagnosis of HB-EGF-Related Cancers. Monoclon Anti Immunodiagn Immunother. 35, 73-82 (2016) Monoclon Antib Immunodiagn Immunother. 35, 73-82 (2016)(PMID:26974561)

The availability is based on the information in Japan at 00:05, Apr 20, 2024 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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