Antibody detailed product information

Code No.	M160-3
Anti-UVRAG mAb
Size	100 µL (1 mg/mL)
Availability (in Japan)	10 or more （In Japan at 00:05, Feb 19, 2026 in JST）
Clonality	Monoclonal
Clone	1H4
Isotype (Immunized Animal)	Mouse IgG1 κ
Applications	WB　1 µg/mL IC*　reported. （PMID: 22310240） IP*　reported. （PMID: 25086043 / 26387534 / 28872463）
Immunogen (Antigen)	Recombinant Human UVRAG (389-699 a.a.)
Reactivity [Gene ID]	Human[7405], Mouse[78610], Rat[308846], Hamster[100751375]
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C
Conjugate	Unlabeled
Manufacturer	MBL
Alternative names	UV radiation resistance associated; p63, DHTX, VPS38
Background	Autophagy is a process of intracellular bulk degradation in which cytoplasmic components including organelles are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for degradation. UVRAG (UV irradiation resistance-associated gene) has been identified as an essential component of the Beclin 1-PI3KC3 complex that suppresses tumorigenicity of human colon and promotes Beclin 1 dependent autophagy.
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Product category	Research area:Autophagy Apoptosis
Data
Citations	Western Blotting Kim J et al. Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 152, 290-303 (2013)(PMID:23332761) Fulcher LJ et al. An affinity-directed protein missile system for targeted proteolysis. Open Biol. 6, 160255 (2016)(PMID:27784791) Cheng Z et al. Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Protein Suppresses Cardiomyocyte Autophagy and Initiates Hypertrophic Growth. J Biol Chem. 292, 2065-2079 (2017)(PMID:27994061) Bartolomeo R et al. mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy. J Clin Invest. 127, 3717-3729 (2017)(PMID:28872463) Immunoprecipitation Kim J et al. Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 152, 290-303 (2013)(PMID:23332761) Zhong Y et al. Nrbf2 protein suppresses autophagy by modulating Atg14L protein-containing Beclin 1-Vps34 complex architecture and reducing intracellular phosphatidylinositol-3 phosphate levels. J Biol Chem. 289, 26021-37 (2014)(PMID:25086043) Nemazanyy I et al. Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. Nat Commun. 6, 8283 (2015)(PMID:26387534) Bartolomeo R et al. mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy. J Clin Invest. 127, 3717-3729 (2017)(PMID:28872463) Immunocytochemistry Huang W et al. Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein. Cell Res. 22, 473-49 (2012)(PMID:22310240)

The availability is based on the information in Japan at 00:05, Feb 19, 2026 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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