Code No. | M100-3 | |
Anti-CD11c (Mouse) mAb | ||
Size | 100 µL (1 mg/mL) | |
Availability (in Japan) | 10 or more
(In Japan at 00:05, Apr 24, 2024 in JST) |
|
Clonality | Monoclonal | |
Clone | 223H7 | |
Isotype (Immunized Animal) |
Rat IgG2a | |
Applications | IP 5 µg/1000 µL of cell extract from 5x106 cells FCM 5-10 µg/mL (final concentration) IH* reported. (PMID: 20042501 / 24695531 / 24752483) |
|
Immunogen (Antigen) |
C57BL/6 Mice-derived dendritic cells | |
Reactivity [Gene ID] | Mouse[16411] |
|
Storage buffer | 1 mg/mL in PBS/50% glycerol, pH 7.2 | |
Storage temp. | -20°C | |
Conjugate | Unlabeled | |
Manufacturer | MBL | |
Alternative names | Itgax, integrin apha X | |
Background | The CD11c (alpha X integrin; ~150 kDa) glycoprotein non-covalently associates with CD18 (beta2 integrin; ~95 kDa) to form the heterodimeric complement receptor type 4 (CR4), which is involved in monocyte/granulocyte adhesion during inflammatory responses. The CD11c/CD18 receptor binds to CD54, iC3b and fibrinogen and plays a role in leukocyte adhesive interactions. CD11c/CD18 is also implicated in B cell proliferation and mediates B cell binding to fibrinogen. CD11c is commonly used as a marker for dendritic cells, but it is also expressed on macrophages, monocytes, granulocytes, NK cells, activated T and B lymphocytes and microglia. | |
Related products | M100-4 Anti-CD11c (Mouse) mAb-FITC M100-6 Anti-CD11c (Mouse) mAb-Biotin |
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Product category | Research area:Immunology Cell surface antigens | |
Data | ||
Citations | Flow Cytometry
Immunohistochemistry
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