Antibody detailed product information

Code No.	K0227-5
Anti-CD8 (Mouse) mAb-PE
Size	1 mL (100 tests)
Availability (in Japan)	10 or more （In Japan at 00:05, Apr 20, 2024 in JST）
Clonality	Monoclonal
Clone	KT15
Isotype (Immunized Animal)	Rat IgG2aλ
Applications	FCM　10 µL (Ready for use.)
Immunogen (Antigen)	T cell clone C6, H-2K^k restricted H-Y antigen specific CTL
Reactivity [Gene ID]	Mouse[12525]
Storage buffer	PBS/1% BSA/0.09% NaN₃
Storage temp.	4°C
Conjugate	PE
Manufacturer	MBL
Background	The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two α chains, or a heterodimer composed of one α and one β chain. Both α and β chains share significant homology to immunoglobulin variable light chains. CD8 α chains binds to class-I MHC molecules α3 domains. CD8 identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. This monoclonal antibody KT15 reacts with a non-polymorphic epitope on the mouse CD8 α chain (mouse Ly2.1 and Ly2.2 cells).
Related products	K0227-4 Anti-CD8 (Mouse) mAb-FITC K0227-A64 Anti-CD8 (Mouse) mAb-Alexa Fluor™ 647
Product category	Research area:Immunology Cell surface antigens
Data

The availability is based on the information in Japan at 00:05, Apr 20, 2024 in JST.
The special price is shown in red color.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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