Antibody detailed product information

Code No.	D355-3
Anti-Dab1 (Mouse) mAb
Size	100 µL (1 mg/mL)
Availability (in Japan)	1-9 （In Japan at 17:00, Jun 13, 2026 in JST）
Clonality	Monoclonal
Clone	4E12
Isotype (Immunized Animal)	Rat IgG2aκ
Applications	WB　1 µg/mL IC*　reported. （PMID: 25149914） IH*　reported. （PMID: 25149914）
Immunogen (Antigen)	Mouse Dab1 (recombinant)
Reactivity [Gene ID]	Mouse[13131]
Storage buffer	"1 mg/mL in PBS/50% glycerol, pH 7.2"
Storage temp.	-20°C
Conjugate	Unlabeled
Manufacturer	MBL
Alternative names	"disabled 1, scm, scr, yot, AI956902, scrambler, C630028C02Rik"
Background	Dab1は、神経細胞の移動・配置、樹状突起の発達などに関与する細胞内アダプタータンパク質で、脳の形成に必須な役割を持つ。クローン4H11は、Dab1のC末（281-460）にエピトープを持ち、クローン4E12はDab1のinternal 領域でPTB（Phosphotyrosine binding ）ドメインの近傍(161-320)にエピトープがある。 Reelinが受容体分子（ApoER2/VLDLR）に結合後、Dab1をリン酸化し、細胞内シグナル伝達が進行する。
Related products	D354-3 Anti-Dab1 (Mouse) mAb D351-3 Anti-Reelin (Mouse) mAb M067-3 Anti-Apolipoprotein E4 (Human) mAb M068-3 Anti-Apolipoprotein E (Human) mAb D352-3 Anti-Kiaa0319 (Mouse) mAb D353-3 Anti-Kiaa0319 (Mouse) mAb
Product category	Research area:Neuroscience
Data
Citations	Western Blotting Onoue A et al. Aberrant fragment of Dab1 protein is present in yotari mouse. Neurosci. Res. 88, 23-7 (2014)(PMID:25149914) Immunocytochemistry Onoue A et al. Aberrant fragment of Dab1 protein is present in yotari mouse. Neurosci. Res. 88, 23-7 (2014)(PMID:25149914) Immunohistochemistry Onoue A et al. Aberrant fragment of Dab1 protein is present in yotari mouse. Neurosci. Res. 88, 23-7 (2014)(PMID:25149914)
References	Uchida T et al. Downregulation of functional Reelin receptors in projection neurons implies that primary Reelin action occurs at early/premigratory stages. J Neurosci. 29, 10653-62 (2009) (PMID:19710317) Morimura T et al. Disabled1 regulates the intracellular trafficking of reelin receptors. J Biol Chem. 280, 16901-8 (2005) (PMID:15718228)

The availability is based on the information in Japan at 17:00, Jun 13, 2026 in JST.
The special price is shown in red color.
Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.