Antibody detailed product information

Code No. D233-3
Anti-Mesothelin (Mouse) mAb
Size 100 µL (1 mg/mL)
Availability (in Japan) 1-9
（In Japan at 00:05, Apr 17, 2024 in JST）
Clonality Monoclonal
Clone B35
Isotype
(Immunized Animal) 		Rat IgG2a
Applications FCM　10 µg/mL  
Function*　reported.  （PMID: 28287406）
Immunogen
(Antigen)		 Mouse hemangioblast-like cell line LO cells
Reactivity [Gene ID]

Mouse[56047]
Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C
Conjugate Unlabeled
Manufacturer MBL
Alternative names Msln, MPF
Background Mesothelin (MSLN) is a GPI-linked cell surface glycoprotein expressed in the mesothelial lining of the body cavities and in mullerian duct epithelium related cancer cells (ovarian, pancreatic cancer, mesothelioma). Both human and mouse mesothelin bind to ovarian cancer antigen CA125/MUC16 with high affinity, mediating cell attachment in vitro, suggesting that mesothelin may facilitate ovarian cancer metastasis.
Related products D233-3 Anti-Mesothelin (Mouse) mAb
M081-3 Rat IgG2a (isotype control)
Product category Research area:Cancer Cell surface antigens
Data

Citations

Function

  1. Koyama Y et al. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. J Clin Invest. 127,1254-1270 (2017)(PMID:28287406)
  • The availability is based on the information in Japan at 00:05, Apr 17, 2024 in JST.
  • The special price is shown in red color.
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  • Abbreviations for applications：
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.
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