Antibody detailed product information

Code No. D217-3
Anti-Desmoglein 3 (Mouse) mAb (No Azide)
Size 100 µL (1 mg/mL)
Availability (in Japan) 10 or more
（In Japan at 17:00, Apr 23, 2024 in JST）
Clonality Monoclonal
Clone AK9
Isotype
(Immunized Animal) 		Mouse IgG1
Applications IP　reported.  （PMID: 12574390）
IC　0.01 µg/mL  
IH　0.01 µg/mL  
Immunogen
(Antigen)		 hybridoma was established by fusion of splenocytes from PV model mouse and P3 mouse myeloma cells
Reactivity [Gene ID]

Human(-), Mouse[13512]
Storage buffer 1 mg/mL in PBS, pH 7.2
Storage temp. 4°C
Conjugate Unlabeled
Manufacturer MBL
Alternative names Dsg3
Background Pemphigus vulgaris (PV) is a life -threatening autoimmune blistering disease of the skin and mucous membranes. In patients of PV, IgG autoantibodies against the cell surface of keratinocytes in stratified squamous epithelia play a major pathogenic role in loss of cell-cell adhesion. The autoimmune target of PV is desmoglein 3 (Dsg3), which is a member of the cadherin family of calcium-depending, transmembrane glycoprotein.
Related products D218-3 Anti-Desmoglein 3 (Mouse) mAb (No Azide)
D219-3 Anti-Desmoglein 3 (Mouse) mAb (No Azide)
M075-3 Mouse IgG1 (isotype control)
Product category Research area:Immunology
Data


Citations

Immunoprecipitation

  1. Tsunoda K, et al., Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3. J Immunol. 170:2170-8. 2003(PMID:12574390)

Immunohistochemistry

  1. Yamaguchi T, et al., Identification of the Staphylococcus aureus etd pathogenicity island which encodes a novel exfoliative toxin, ETD, and EDIN-B. Infect Immun. 70:5835-45. 2002(PMID:12228315)
  • The availability is based on the information in Japan at 17:00, Apr 23, 2024 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications：
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.
MBLCopyright (C)2015 Medical ＆ Biological Laboratories Co., Ltd. All Rights Reserve