Antibody detailed product information

Code No.	D092-3M2
Anti-CD274 (PD-L1) (Human) mAb (Functional Grade)
Size	100 µL (1 mg/mL)
Availability (in Japan)	1-9 （In Japan at 00:05, Jun 7, 2026 in JST）
Clonality	Monoclonal
Clone	MIH3
Isotype (Immunized Animal)	Mouse IgG1
Applications	FCM　5-10 µg/mL Other(Adhesion Assay )　reported. （PMID: 18585785）
Immunogen (Antigen)	L cells transfected full length human PD-L1 protein
Reactivity [Gene ID]	Human[29126]
Storage temp.	-20°C
Conjugate	Unlabeled
Manufacturer	MBL
Alternative names	"B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1"
Background	"Programmed death ligand 1 (PD-L1, also known as CD274/B7-H1), a member of B7 family was identified by searching for molecules that share homology with the immunogloblin V and C domains of B7-1 and B7-2 among the human cDNA expressed sequence tags in the National Center for Biotechnology Information database. PD-L1 is a ligand for programmed death 1 (PD-1) which belongs to the CD28/CTLA4 subfamily. Although in vitrostudy indicated that the cross-linking of PD-1 by PD-L1 leads to down-regulation of T-cell responses, some studies have shown that T cells stimulated with low levels of anti-CD3 and immobilized PD-L1-Ig were activated, proliferation and production of IFN-g GM-CSF and IL-10 from the T cells were enhanced. The role of PD-L1 is now debatable."
Related products	D092-3 Anti-CD274 (PD-L1) (Human) mAb M075-3M2 Mouse IgG1 (isotype control) (Functional Grade)
Product category	Research area:Immunology Cell surface antigens
Data

The availability is based on the information in Japan at 00:05, Jun 7, 2026 in JST.
The special price is shown in red color.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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