Code No. | D038-3 | |
Anti-Bcl-2 mAb | ||
Size | 100 µL (1 mg/mL) | |
Availability (in Japan) | 10 or more
(In Japan at 17:33, Apr 26, 2024 in JST) |
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Clonality | Monoclonal | |
Clone | 83-8B | |
Isotype (Immunized Animal) |
Mouse IgG1 | |
Applications | WB 1 µg/mL FCM 10 µg/mL |
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Immunogen (Antigen) |
Recombinant rat Bcl-2β | |
Reactivity [Gene ID] | ||
Storage buffer | 1 mg/mL in PBS/50% glycerol, pH 7.2 | |
Storage temp. | -20°C | |
Conjugate | Unlabeled | |
Manufacturer | MBL | |
Alternative names | B-cell CLL/lymphoma 2, BCL2, PPP1R50 | |
Background | The Bcl-2 related genes can inhibit (Bcl-XL and Mcl-1) or induce (Bax, Bcl-Xs, Bag and Bad) apoptosis in several systems. Bad was identified as a Bcl-2 interacting protein using a yeast two-hybrid screening and l expression cloning. It has homology to Bcl-2 within the Bcl-2 homolog domains 1 and 2 (BH1 and BH2). In mammalian cells, Bad selectively heterodimerizes with Bcl-XL as well as Bcl-2, but not with other Bcl-2 family members (Bax, Bcl-Xs, Mcl-1 and A1). When Bad heterodimerized with Bcl-XL, it displaced Bax from Bcl-XL and promoted cell death. | |
Related products | M200-3 Anti-NRF2 mAb PD017 Anti-Beclin 1 pAb PM069 Anti-NRF2 pAb |
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Product category | Research area:Apoptosis | |
Data | ||
Citations | Western Blotting
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