Antibody detailed product information

Code No.	CM005-3
Anti-SynCAM (TSLC1/CADM1) (Human) mAb
It is reported that clone 9D2 can be used in adhesion blocking experiments in the references.
Size	100 µL (1 mg/mL)
Availability (in Japan)	10 or more （In Japan at 17:33, Apr 26, 2024 in JST）
Clonality	Monoclonal
Clone	9D2
Isotype (Immunized Animal)	Chicken IgY
Applications	FCM　1 µg/mL (final concentration)
Immunogen (Antigen)	Recombinant SynCAM/Fc fusion protein
Reactivity [Gene ID]	Human[23705]
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C
Conjugate	Unlabeled
Manufacturer	MBL
Alternative names	cell adhesion molecule 1, BL2, IGSF4, IGSF4A, NECL2, Necl-2, RA175, ST17, sTSLC-1, sgIGSF
Background	SynCAM (Synaptic Cell Adhesion Molecule), also known as TSLC1 (tumor suppressor in lung cancer-1), SgIGSF, or CADM1, is a homophilic, transmembrane Ig-domain containing protein with intracellular PDZ protein-binding motifs. Although originally identified as a tumor suppressor of small lung cell carcinomas, SynCAM appears to be primarily involved in intracellular adhesion and synapse formation. The majority of SynCAM is localized to synaptic sites where it initiates synaptic assembly and synapse differentiation throughout the central nervous system. SynCAM also mediates the cellular adhesion of spermatogenic cells to Sertoli cells and mast cells to fibroblasts.
Related products	PM084 Normal Chicken IgY PM084-4 Normal Chicken IgY-FITC PM084-5 Normal Chicken IgY-PE CM004-3 Anti-SynCAM (TSLC1/CADM1) mAb CM004-4 Anti-SynCAM (TSLC1/CADM1) mAb-FITC CM004-5 Anti-SynCAM (TSLC1/CADM1) mAb-PE CM004-6 Anti-SynCAM (TSLC1/CADM1) mAb-Biotin CM004-A64 Anti-SynCAM (TSLC1/CADM1) mAb-Alexa Fluor™ 647
Product category	Research area:Neuroscience
Data
References	Furuno T et al. The spermatogenic Ig superfamily/synaptic cell adhesion molecule mast-cell adhesion molecule promotes interaction with nerves. J Immunol. 174, 6934-42 (2005)（PMID: 15905536） Yang W et al. Human lung mast cells adhere to human airway smooth muscle, in part, via tumor suppressor in lung cancer-1. J Immunol. 176, 1238-43 (2006)（PMID: 16394014） Hollins F et al. Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6. J Immunol. 181, 2772-80 (2008)（PMID: 18684968 ） Moiseeva EP et al. CADM1 controls actin cytoskeleton assembly and regulates extracellular matrix adhesion in human mast cells. PLoS One 9, e85980 (2014)（PMID: 24465823） Murakami S et al. Trans-homophilic interaction of CADM1 activates PI3K by forming a complex with MAGuK-family proteins MPP3 and Dlg. PLoS One 9, e110062 (2014)（PMID: 25268382）

The availability is based on the information in Japan at 17:33, Apr 26, 2024 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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