Anti-Inosine pAb

Availability (in Japan)

10 or more

（In Japan at 17:00,
Oct 8, 2024 in JST）

Size

100 µL

Related information

・

Data Sheet

SDS

Data	Immunoprecipitation Immunoprecipitation Immunocytochemistry Immunohistochemistry
Clonality	Polyclonal
Isotype (Immunized Animal)	Rabbit Ig (aff.)
Applications	IP 10 µL/sample IC 1:100-1:200 IH** Can be used. ELISA Can be used. DB Can be used.
Immunogen (Antigen)	Carrier protein-conjugated Inosine
Storage buffer	PBS/50% glycerol, pH 7.2
Storage temp.	-20°C	Conjugate	Unlabeled	Manufacturer	MBL
Alternative names	Ino, I
Background	Adenosine-to-inosine (A-to-I) RNA editing, the most common modification that occurs in mammalian mRNAs and ncRNAs, is the conversion of adenosine to inosine catalyzed by members of the adenosine deaminase acting on RNA (ADAR) family. Because inosine has a similar chemical structure to guanosine, it pairs preferentially with cytidine. This influences the regulation of splicing, stabilization, and translation. A-to-I RNA editing also affects miRNA biogenesis and their recognition by target mRNAs. A malfunction in the editing mechanism results in various human diseases such as neurological disorders and cancers.
Related products	D347-3 Anti-Pseudouridine mAb D345-3 Anti-1-methyladenosine (m¹A) mAb D346-3 Anti-5-methylcytidine (m⁵C) mAb PM077 Anti-5-hydroxymethylcytosine (5hmC) pAb MI-11-3 Anti-Bromodeoxyuridine mAb MI-11-5 Anti-Bromodeoxyuridine mAb-PE M218-3 Anti-5-hydroxymethylcytosine (5hmC) mAb RN019M Anti-2,2,7-trimethylguanosine (m₃G/TMG) mAb RN016M Anti-7-methylguanosine (m⁷G)-Cap mAb RN017M Anti-7-methylguanosine (m⁷G) mAb
References	Morse DP, Bass BL. Detection of inosine in messenger RNA by inosine-specific cleavage. Biochemistry 36, 8429-34 (1997)（PMID: 9264612） Zinshteyn B, Nishikura K. Adenosine-to-inosine RNA editing. Wiley Interdiscip Rev Syst Biol Med. 1, 202-9 (2009)（PMID: 20835992） Nigita G et al. A-to-I RNA Editing: Current Knowledge Sources and Computational Approaches with Special Emphasis on Non-Coding RNA Molecules. Front Bioeng Biotechonol. 3, 37 (2015)（PMID: 25859542） Nishikura K. A-to-I editing of coding and non-coding RNAs by ADARs. Nat Rev Mol Cell Biol. 17, 83-96 (2016)（PMID: 26648264）
Product category	Research area RNA-RNP Network Epigenetics

The availability is based on the information in Japan at 17:00, Oct 8, 2024 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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