Anti-Desmoglein 3 (Mouse) mAb (No Azide)

Availability (in Japan)

10 or more

（In Japan at 00:05,
Apr 19, 2024 in JST）

Size

100 µL (1 mg/mL)

Citations

Data Sheet

SDS

Data	Immunocytochemistry Immunohistochemistry
Clonality	Monoclonal	Clone	AK18
Isotype (Immunized Animal)	Mouse IgG1
Applications	IP* reported. （PMID: 12574390） IC 0.1 µg/mL IH 0.1 µg/mL
Reactivity [Gene ID]	Human(w)[1830], Mouse[13512]
Storage buffer	1 mg/mL in PBS, pH 7.2
Storage temp.	4°C	Conjugate	Unlabeled	Manufacturer	MBL
Alternative names	DSG3, PVA, CDHF6
Background	Pemphigus vulgaris (PV) is a life -threatening autoimmune blistering disease of the skin and mucous membranes. In patients of PV, IgG autoantibodies against the cell surface of keratinocytes in stratified squamous epithelia play a major pathogenic role in loss of cell-cell adhesion. The autoimmune target of PV is desmoglein 3 (Dsg3) which is a member of the cadherin family of calcium-depending, transmembrane glycoprotein.
Related products	D217-3 Anti-Desmoglein 3 (Mouse) mAb (No Azide) D219-3 Anti-Desmoglein 3 (Mouse) mAb (No Azide)
Citations	Western Blotting Culton DA et al. Mucosal pemphigus vulgaris anti-Dsg3 IgG is pathogenic to the oral mucosa of humanized Dsg3 mice. J Invest Dermatol. 135, 1590-7 (2015)(PMID:25695683) Immunoprecipitation Tsunoda K et al. Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3. J Immunol. 170, 2170-8 (2003)(PMID:12574390) Immunohistochemistry Culton DA et al. Mucosal pemphigus vulgaris anti-Dsg3 IgG is pathogenic to the oral mucosa of humanized Dsg3 mice. J Invest Dermatol. 135, 1590-7 (2015)(PMID:25695683) Fujii E et al. Tissue-specific Effects of an anti-desmoglein-3 ADCC Antibody Due to Expression of the Target Antigen and Physiological Characteristics of the Mouse Vagina. J Toxicol Pathol. 33, 67-76 (2020)(PMID:32425339)
Product category	Research area Immunology

The availability is based on the information in Japan at 00:05, Apr 19, 2024 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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