HOME > Product search results > Code No. CM004-A64 Anti-SynCAM (TSLC1/CADM1) mAb-Alexa Fluor™ 647

Code No.　CM004-A64

Anti-SynCAM (TSLC1/CADM1) mAb-Alexa Fluor™ 647

Availability (in Japan)

10 or more

（In Japan at 17:00,
Apr 18, 2024 in JST）

Size

100 µL (1 mg/mL)

Data Sheet

SDS

Data	Flow Cytometry
Clonality	Monoclonal	Clone	3E1
Isotype (Immunized Animal)	Chicken IgY
Applications	FCM 1 µg/mL
Immunogen (Antigen)	Recombinant Fc-SynCAM fusion protein
Reactivity [Gene ID]	Human[23705]
Storage buffer	1 mg/mL in PBS/1% BSA/0.1% ProClin 150
Storage temp.	4°C	Conjugate	Alexa Fluor® 647	Manufacturer	MBL
Alternative names	cell adhesion molecule 1, BL2, IGSF4, IGSF4A, NECL2, Necl-2, RA175, ST17, sTSLC-1, sgIGSF
Background	SynCAM (Synaptic Cell Adhesion Molecule), also known as TSLC1 (tumor suppressor in lung cancer-1), SgIGSF, or CADM1, is a homophilic, transmembrane Ig-domain containing protein with intracellular PDZ protein-binding motifs. Although originally identified as a tumor suppressor of small lung cell carcinomas, SynCAM appears to be primarily involved in intracellular adhesion and synapse formation. The majority of SynCAM is localized to synaptic sites where it initiates synaptic assembly and synapse differentiation throughout the central nervous system. SynCAM also mediates the cellular adhesion of spermatogenic cells to Sertoli cells and mast cells to fibroblasts.
Related products	CM004-3 Anti-SynCAM (TSLC1/CADM1) mAb CM005-3 Anti-SynCAM (TSLC1/CADM1) (Human) mAb PM084 Normal Chicken IgY PM084-4 Normal Chicken IgY-FITC PM084-5 Normal Chicken IgY-PE CM004-4 Anti-SynCAM (TSLC1/CADM1) mAb-FITC CM004-5 Anti-SynCAM (TSLC1/CADM1) mAb-PE CM004-6 Anti-SynCAM (TSLC1/CADM1) mAb-Biotin
References	Fogel AI et al. SynCAMs organize synapses through heterophilic adhesion. J Neurosci. 27, 12516-12530 (2007)（PMID: 18003830） Fujita E et al. Loss of partitioning-defective-3/isotype-specific interacting protein (par-3/ASIP) in the elongating spermatid of RA175 (IGSF4A/SynCAM)-deficient mice. Am J Pathol. 171, 1800-1810 (2007)（PMID: 18055550） Hollins F et al. Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6. J Immunol. 181, 2772-2780 (2008)（PMID: 18684968） Hasstedt SJ et al. Cell adhesion molecule 1: a novel risk factor for venous thrombosis. Blood. 114, 3084-3091 (2009)（PMID: 19643986） Hagiyama M et al. Expression of a soluble isoform of cell adhesion molecule 1 in the brain and its involvement in directional neurite outgrowth. Am J Pathol. 174, 2278-2289 (2009)（PMID: 19435791） Yang W et al. Human lung mast cells adhere to human airway smooth muscle, in part, via tumor suppressor in lung cancer-1. J Immunol. 176, 1238-1243 (2006)（PMID: 16394014） Wakayama T et al. Heterophilic binding of the adhesion molecules poliovirus receptor and immunoglobulin superfamily 4A in the interaction between mouse spermatogenic and Sertoli cells. Biol Reprod. 76, 1081-1090 (2007)（PMID: 17314315）
Product category	Research area Cancer Neuroscience

The availability is based on the information in Japan at 17:00, Apr 18, 2024 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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