Anti-ATAD2 (ANCCA) (Human) mAb

Availability (in Japan)

10 or more

（In Japan at 17:00,
Apr 19, 2024 in JST）

Size

100 µL (1 mg/mL)

Data Sheet

SDS

Data	Western Blotting Immunoprecipitation Immunocytochemistry Immunohistochemistry
Clonality	Monoclonal	Clone	C20-19
Isotype (Immunized Animal)	Mouse IgG1 κ
Applications	WB 1 μg/mL IP 5 μg/sample IC 1 μg/mL IH 5 μg/mL (Heat treatment is necessary for paraffin embedded sections.)
Immunogen (Antigen)	Recombinant protein, corresponding to amino acids 1159-1350 of human ATAD2 (ANCCA)
Reactivity [Gene ID]	Human[29028], Mouse(-), Rat(-), Monkey(-)
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C	Conjugate	Unlabeled	Manufacturer	MBL
Alternative names	ATPase family AAA domain-containing protein 2, CT137, PRO2000
Background	ATAD2, also known as ANCCA, belongs to the AAA type ATPase family and contains a bromodomain, which involves in recognition of an epigenetic histone modification (acetylated lysine). High expression levels of ATAD2 protein are observed in various cancer tissues, and its overexpression in breast and lung cancer is associated with poor tumor prognosis. The bromodomain region of ATAD2 is increasingly targeted for chemical inhibitors used to treat cancer.
Related products	M075-3 Mouse IgG1 (isotype control)
References	Kalashnikova EV et al. ANCCA/ATAD2 overexpression identifies breast cancer patients with poor prognosis, acting to drive proliferation and survival of triple-negative cells through control of B-Myb and EZH2. Cancer Res 70, 9402-12 (2010)（PMID: 20864510） Ciró M et al. ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors. Cancer Res 69, 8491-8 (2009)（PMID: 19843847）
Product category	Research area Epigenetics Cancer

The availability is based on the information in Japan at 17:00, Apr 19, 2024 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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