Anti-Syntaxin-17 (Human) mAb

Availability (in Japan)

10 or more

（In Japan at 00:05,
Apr 20, 2024 in JST）

Size

100 µL (1 mg/mL)

Citations

Data Sheet

SDS

Data	Western Blotting Immunoprecipitation
Clonality	Monoclonal	Clone	2F8
Isotype (Immunized Animal)	Mouse IgG2aκ
Applications	WB 1 µg/mL IP 2 µg/sample IC* reported. （PMID: 29290589）
Immunogen (Antigen)	Human Syntaxin-17, recombinant protein
Reactivity [Gene ID]	Human[55014], Mouse(-), Rat(-), Hamster(-)
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C	Conjugate	Unlabeled	Manufacturer	MBL
Background	Syntaxin 17 (Stx17) is the autophagosomal SNARE protein required for fusion with the endosome/lysosome. Stx17 localizes to the completed autophagosomes but not to the isolation membrane. Stx17 is essential for its selective targeting to the outer autophagosomal membrane and available to the completed autophagosome.
Related products	PM076 Anti-Syntaxin-17 (Human) pAb
Citations	Western Blotting Yamashita SI et al. Mitochondrial division occurs concurrently with autophagosome formation but independently of Drp1 during mitophagy. J Cell Biol. 215, 649-665 (2016)(PMID:27903607) Immunocytochemistry Smith MD et al. CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis. Dev Cell. 44, 217-232.e11 (2018)(PMID:29290589)
References	Hamasaki M et al. Autophagosomes form at ER-mitochondria contact sites. Nature 495, 389-93 (2013)（PMID: 23455425） Itakura E et al. The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. Cell 151, 1256-69 (2012)（PMID: 23217709）
Product category	Research area Autophagy

The availability is based on the information in Japan at 00:05, Apr 20, 2024 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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