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Product search results > Code No. M137-3
Anti-HMGB1 (HMG1) mAb
Code No. M137-3
Anti-HMGB1 (HMG1) mAb
Availability (in Japan)
10 or more
（In Japan at 00:05,
Apr 18, 2024 in JST）
Size
100 µL (1 mg/mL)
Citations
Data Sheet| Data |
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| Clonality | Monoclonal | Clone | 4C9 | ||
| Isotype (Immunized Animal) | Mouse IgG1 | ||||
| Applications |
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| Immunogen (Antigen) | Human HMGB1 internal region synthetic peptide | ||||
| Reactivity [Gene ID] | |||||
| Storage buffer | 1 mg/mL in PBS/50% glycerol, pH 7.2 | ||||
| Storage temp. | -20°C | Conjugate | Unlabeled | Manufacturer | MBL |
| Alternative names | SBP-1 | ||||
| Background | High mobility group box 1 (HMGB1), named for its rapid migration properties on electrophoretic gels, is a member of the nonhistone chromatin-associated proteins. HMGB1 is translated as a 214 amino acid protein, and extensively modified posttranslationally, by glycosylation, acylation, methylation, and phosphorylation. The primary structure is evolutionarily conserved, with 100% amino acid sequence homology between rat and mouse, and 99% homology between rodent and human. Intracellular HMGB1 has been studied previously for its roles in binding DNA; stabilizing nucleosome formation; as a general transcription factor for nucleolar and mitochondrial RNA polymerases; and as a gene- and tissue-specific transcriptional regulator that can enhance transcription and/or replication. Extracellular HMGB1 is recently implicated as a late mediator of delayed endotoxin lethality, because murine and human macrophages/monocytes release large amounts of a 29 kDa form of HMGB1 when stimulated by exposure to bacterial endotoxin. | ||||
| Related products | D075-3 Anti-HMGB1 (HMG1) mAb PD017 Anti-Beclin 1 pAb |
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| Citations |
Immunofluorescence
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- The availability is based on the information in Japan at 00:05, Apr 18, 2024 in JST.
- The special price is shown in red color.
- Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
- Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation - For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
- For storage temparature: RT: room temparature
- Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.