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HOME > Product search results > Code No. M100-3 Anti-CD11c (Mouse) mAb

Code No. M100-3

Anti-CD11c (Mouse) mAb

Availability (in Japan)

1-9

(In Japan at 17:00,
Dec 13, 2019 in JST)

Size

100 µg/100 µL

Data
  • Immunoprecipitation

  • Flow Cytometry

Clonality Monoclonal Clone 223H7
Isotype (Immunized Animal) Rat IgG2a
Applications
IP
5 µg/1000 µL of cell extract from 5x106 cells  
FCM
5-10 µg/mL (final concentration)  
IH*
reported.  (PMID: 20042501 / 24695531 / 24752483
Immunogen (Antigen) C57BL/6 Mice-derived dendritic cells
Reactivity [Gene ID]

Mouse[16411]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names Itgax, integrin apha X
Background The CD11c (alpha X integrin; ~150 kDa) glycoprotein non-covalently associates with CD18 (beta2 integrin; ~95 kDa) to form the heterodimeric complement receptor type 4 (CR4), which is involved in monocyte/granulocyte adhesion during inflammatory responses. The CD11c/CD18 receptor binds to CD54, iC3b and fibrinogen and plays a role in leukocyte adhesive interactions. CD11c/CD18 is also implicated in B cell proliferation and mediates B cell binding to fibrinogen.  CD11c is commonly used as a marker for dendritic cells, but it is also expressed on macrophages, monocytes, granulocytes, NK cells, activated T and B lymphocytes and microglia.
Related products M100-4 Anti-CD11c (Mouse) mAb-FITC
M100-6 Anti-CD11c (Mouse) mAb-Biotin
Citations

Flow Cytometry

  1. Crawford JR et al. FcγRI mediates serum amyloid P inhibition of fibrocyte differentiation. J Leukoc Biol. 92, 699-711 (2012)(PMID:22493081)
  2. Pilling D, Gomer RH. Persistent lung inflammation and fibrosis in serum amyloid P component (APCs-/-) knockout mice. PLoS One 9, e93730 (2014)(PMID:24695531)

Immunohistochemistry

  1. Ferreira CS et al. Measles virus infection of alveolar macrophages and dendritic cells precedes spread to lymphatic organs in transgenic mice expressing human signaling lymphocytic activation molecule (SLAM, CD150). J Virol. 84, 3033-42 (2010)(PMID:20042501)
  2. Pilling D, Gomer RH. Persistent lung inflammation and fibrosis in serum amyloid P component (APCs-/-) knockout mice. PLoS One 9, e93730 (2014)(PMID:24695531)
  3. Catani JP et al.Intratumoral Immunization by p19Arf and Interferon-β Gene Transfer in a Heterotopic Mouse Model of Lung Carcinoma. Transl Oncol. 9, 565-574 (2016)(PMID:24752483)
Product category
Research area
Immunology
Cell surface antigens
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 17:00, Dec 13, 2019 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.