Availability (in Japan)
1-9
(In Japan at 17:00,
Mar 29, 2024 in JST)
Size
100 µL (1 mg/mL)
Data | |||||
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Clonality | Monoclonal | Clone | 1F9 | ||
Isotype (Immunized Animal) | Mouse IgG1 | ||||
Applications |
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Immunogen (Antigen) | Recombinant Human caspase-3 | ||||
Reactivity [Gene ID] | Human[836], Mouse(-), Rat(-) |
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Storage buffer | 1 mg/mL in PBS/50% glycerol, pH 7.2 | ||||
Storage temp. | -20°C | Conjugate | Unlabeled | Manufacturer | MBL |
Alternative names | CASP3 | ||||
Background | Caspase-3 (also known as CPP32, Yama, apopain) is a key member of the caspase family of cysteine proteases. Caspase-3 exists in cells as an inactive 32 kDa proenzyme. During apoptosis procaspase-3 is processed at aspartate residues by self-proteolysis and/or cleavage by upstream caspases, such as caspase-6, -8, or -9. The processed form of caspase-3 consists of large (17 kDa) and small (12 kDa) subunits which associate to form the active tetrameric enzyme tetramer (a pair of heterodimers). The active caspase-3 proteolytically cleaves and activates other caspases, as well as relevant targets in the cells (e.g., PARP, SREBPs, and DFF). Activation of procaspase-3 stands at a point of convergence for the two major types of apoptosis signaling pathways-those linked to cell surface death receptors and those linked to mitochondrial release of cytochrome c. | ||||
Related products | M097-3 Anti-Caspase-3 (Human) mAb M059-3 Anti-Caspase-10 (Human) mAb M029-3 Anti-Caspase-4 (Human) mAb M060-3 Anti-Caspase-5 mAb M053-3 Anti-Caspase-7 mAb M032-3 Anti-Caspase-8 (Human) mAb M058-3 Anti-Caspase-8 (Human) mAb M054-3 Anti-Caspase-9 mAb M044-3 Anti-XIAP (MIHA/ILP-a) mAb |
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