Availability (in Japan)
10 or more
(In Japan at 17:00,
Dec 4, 2024 in JST)
Size
1 mL (100 tests)
Data | |||||
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Clonality | Monoclonal | Clone | KT15 | ||
Isotype (Immunized Animal) | Rat IgG2aλ | ||||
Applications |
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Immunogen (Antigen) | T cell clone C6, H-2Kk restricted H-Y antigen specific CTL | ||||
Reactivity [Gene ID] | Mouse[12525] |
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Storage buffer | PBS/1% BSA/0.1% ProClin 150 | ||||
Storage temp. | 冷蔵 | Conjugate | FITC | Manufacturer | MBL |
Background | The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two α chains, or a heterodimer composed of one α and one β chain. Both α and β chains share significant homology to immunoglobulin variable light chains. CD8 α chains bind to class-I MHC molecules α3 domains. CD8 identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing.This monoclonal antibody KT15 reacts with a non-polymorphic epitope on the mouse CD8 α chain (mouse Ly2.1 and Ly2.2 cells). | ||||
Related products | M081-4 Rat IgG2a (isotype control)-FITC D341-4 Anti-CD4 (Mouse) mAb-FITC |
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