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HOME > Product search results > Code No. D354-3 Anti-Dab1 (Mouse) mAb

Code No. D354-3

Anti-Dab1 (Mouse) mAb

Availability (in Japan)

1-9

(In Japan at 17:00,
Dec 13, 2019 in JST)

Size

100 µg/100 µL

Data
  • Western Blotting

Clonality Monoclonal Clone 4H11
Isotype (Immunized Animal) Rat IgG1 κ
Applications
WB
1 µg/mL  
IC*
reported.  (PMID: 25149914
IH*
reported.  (PMID: 25149914
Immunogen (Antigen) Mouse Dab1 (recombinant)
Reactivity [Gene ID]

Mouse[13131]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names disabled 1, scm, scr, yot, AI956902, scrambler, C630028C02Rik
Background Dab1は、神経細胞の移動・配置、樹状突起の発達などに関与する細胞内アダプタータンパク質で、脳の形成に必須な役割を持つ。

クローン4H11は、Dab1のC末(281-460)にエピトープを持ち、クローン4E12はDab1のinternal 領域でPTB(Phosphotyrosine binding )ドメインの近傍(161-320)にエピトープがある。

Reelinが受容体分子(ApoER2/VLDLR)に結合後、Dab1をリン酸化し、細胞内シグナル伝達が進行する。

 

Related products D354-3 Anti-Dab1 (Mouse) mAb
D355-3 Anti-Dab1 (Mouse) mAb
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M067-3 Anti-Apolipoprotein E4 (Human) mAb
M068-3 Anti-Apolipoprotein E (Human) mAb
D352-3 Anti-Kiaa0319 (Mouse) mAb
D353-3 Anti-Kiaa0319 (Mouse) mAb
D351-3 Anti-Reelin (Mouse) mAb
Citations

Western Blotting

  1. Onoue A et al. Aberrant fragment of Dab1 protein is present in yotari mouse. Neurosci. Res. 88, 23-7 (2014)(PMID:25149914)

Immunocytochemistry

  1. Onoue A et al. Aberrant fragment of Dab1 protein is present in yotari mouse. Neurosci. Res. 88, 23-7 (2014)(PMID:25149914)

Immunohistochemistry

  1. Onoue A et al. Aberrant fragment of Dab1 protein is present in yotari mouse. Neurosci. Res. 88, 23-7 (2014)(PMID:25149914)
References
  1. Uchida T et al. Downregulation of functional Reelin receptors in projection neurons implies that primary Reelin action occurs at early/premigratory stages. J Neurosci. 29, 10653-62 (2009) (PMID:19710317)
  2. Morimura T et al. Disabled1 regulates the intracellular trafficking of reelin receptors. J Biol Chem. 280, 16901-8 (2005) (PMID:15718228)
Product category
Research area
Neuroscience
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 17:00, Dec 13, 2019 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.