Anti-CLOCK (Mouse) mAb

Availability (in Japan)

10 or more

（In Japan at 17:00,
Oct 28, 2021 in JST）

Size

100 µg/100 µL

Citations

Data Sheet

SDS

The immunogen of this antibody (clone CLSP3) is Ser/Pro-rich region of mouse Clock. This antibody can react with mouse and human Clock.

Data	Western Blotting Western Blotting
Clonality	Monoclonal	Clone	CLSP3
Isotype (Immunized Animal)	Mouse IgG1 κ
Applications	WB 1 μg/mL IP** Can be used (Info. from the licenser.) ChIP* （PMID: 24591654 / 24637114）
Immunogen (Antigen)	Ser/Pro-rich region (Ser³⁷⁷-Glu⁵⁵⁶) of mouse Clock
Reactivity [Gene ID]	Human[9575], Mouse[12753]
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C	Conjugate	Unlabeled	Manufacturer	MBL
Alternative names	KAT13D, bHLHe8, mKIAA0334, 5330400M04Rik, circadian locomotor output cycles kaput
Related products	D334-3 Anti-CLOCK (Mouse) mAb D335-3 Anti-BMAL1 mAb CY-P1016 Anti-SIRT1 pAb RN032P Anti-CIRBP pAb PM092 Anti-NR1D1 (Rev-erbα) pAb PM087 Anti-Chrono (Mouse) pAb D349-3 Anti-CLOCK mAb M225-3 Anti-NFIL3 (E4BP4) chimeric mAb PM079 Anti-DBP (Mouse) pAb PM081 Anti-Cry1 (Mouse) pAb PM082 Anti-Cry2 (Mouse) pAb PM083 Anti-Per2 (Mouse) pAb PM096 Anti-PER2 (Human) pAb PM097 Anti-NFIL3 (E4BP4) pAb M219-3 Anti-RORγt mAb PM080 Anti-RORγt pAb PM091 Anti-Per1 (Mouse) pAb PM093 Anti-NR1D2 (Rev-erbβ) pAb
Citations	Western Blotting Yoshitane H et al. Roles of CLOCK phosphorylation in suppression of E-box-dependent transcription. Mol Cell Biol 29, 3675-86 (2009)(PMID:19414601) Yoshitane H et al. JNK regulates the photic response of the mammalian circadian clock. EMBO Rep. 13, 455-61 (2012)(PMID:22441692) Kon N et al. CaMKII is essential for the cellular clock and coupling between morning and evening behavioral rhythms. Genes Dev. 28, 1101-10 (2014)(PMID:24831701) Masuda S et al. Mutation of a PER2 phosphodegron perturbs the circadian phosphoswitch. Proc Natl Acad Sci U S A. 117, 10888-10896 (2020)(PMID:32354999) ChIP Yoshitane H et al. CLOCK-controlled polyphonic regulation of circadian rhythms through canonical and noncanonical E-boxes. Mol Cell Biol 34, 1776-87 (2014)(PMID:24591654) Pekovic-Vaughan V et al. The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis. Genes Dev. 28, 548-60 (2014)(PMID:24637114)
Product category	Research area Circadian rhythm Signal transduction

The availability is based on the information in Japan at 17:00, Oct 28, 2021 in JST.
The special price is shown in red color.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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