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HOME > Product search results > Code No. D204-3 Anti-CD52 (CAMPATH-1) (Mouse) mAb

Code No.　D204-3

Anti-CD52 (CAMPATH-1) (Mouse) mAb

Availability (in Japan)

10 or more

（In Japan at 17:00,
Apr 19, 2024 in JST）

Size

100 µL (1 mg/mL)

Data

  • Flow Cytometry
Clonality Monoclonal Clone BTG-2G
Isotype (Immunized Animal) Rat IgG2a
Applications
IP
Can be used.  
FCM
10 µg/mL (final concentration)  
Function*
reported.  （PMID: 29899181）
Immunogen (Antigen) mouse IL-2R alpha-transgenic mouse splenocytes
Reactivity [Gene ID]

Mouse[23833]
Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Background CAMPATH-1, also known as CD52, is a heavily glycosylated, GPI-anchored protein expressed at high levels on almost all thymocytes, lymphocytes, monocytes, and macrophages. The function of CD52 is unknown. However, CD52 is an exceptionally good target for complement-mediated cell lysis and antibody-mediated cellular cytotoxicity. Humanized CAMPATH-1antibodies have been used therapeutically to effectively deplete lymphocytes in allogeneic bone marrow transplants, hematologic malignancies, and autoimmune diseases. Clinical trials suggest CAMPATH-1 antibodies are especially promising in the treatment of leukemia, non-Hodgkin lymphomas, and rheumatoid arthritis. The apparent size of CAMPATH-1 by SDS-PAGE is 25-29 kDa; however, the actual molecule is much smaller, ~8-9 kDa as confirmed by total structure analysis and mass spectrometry.
Related products D204-5 Anti-CD52 (CAMPATH-1) (Mouse) mAb-PE
D204-4 Anti-CD52 (CAMPATH-1) (Mouse) mAb-FITC
Citations
  1. Sakuragi J et al. A rapid recombination assay of HIV-1 using murine CD52 as a novel biomarker. Microbes Infect. 10, 396-404 (2008)(PMID:18407776)

Function

  1. Liu J et al. Anti-mouse CD52 Treatment Ameliorates Colitis through Suppressing Th1/17 Mediated Inflammation and Promoting Tregs Differentiation in IL-10 Deficient Mice. Biol Pharm Bull. 41, 1423-1429 (2018)(PMID:29899181)
  2. Han Y et al. Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma. Nat Commun. 11, 1776 (2020)(PMID:32296059)
Product category
Research area
Immunology
Cancer
Cell surface antigens
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  • The availability is based on the information in Japan at 17:00, Apr 19, 2024 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications：
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.