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HOME > Product search results > Code No. D184-3 Anti-Granulysin (Human) mAb

Code No.　D184-3

Anti-Granulysin (Human) mAb

Availability (in Japan)

10 or more

（In Japan at 17:00,
Apr 20, 2024 in JST）

Size

100 µL (1 mg/mL)

Data

  • Flow Cytometry
Clonality Monoclonal Clone RB1
Isotype (Immunized Animal) Mouse IgG1 κ
Applications
IP
10 µg/200 µL of cell extract from 5x106 cells  
FCM
10 µg/mL (final concentration)  
IC
10 µg/mL  
ELISA*
reported.  （PMID: 23801887）
Immunogen (Antigen) Full-length human Granulysin expressing plasmids
Reactivity [Gene ID]

Human[10578]
Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names GNLY
Background Granulysin is an antimicrobial protein expressed on cytotoxic T cells, natural killer (NK) cells and NKT cells. It has been shown that Granulysin contributes to the defence mechanisms against variety of mycobacterial infection and tumors. Granulysin has two molecular forms, 15-kDa precursor and 9-kDa effector form. There serum levels were significantly elevated during the acute viral infections and correlated with the NK cell and CTL activities in patients with sever immunodeficiency, indicate that serum Granulysin could be useful novel marker to evaluate the overall status of host cell immunity.
Related products D185-3 Anti-Granulysin (Human) mAb
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D186-3 Anti-Granulysin (Human) mAb
Citations
  1. Fujita Y et al. Rapid immunochromatographic test for serum granulysin is useful for the prediction of Stevens-Johnson syndrome and toxic epidermal necrolysis. J Am Acad Dermatol. 65, 65-8 (2011)(PMID:21507517)
  1. Ogawa K et al. Granulysin in human serum as a marker of cell-mediated immunity. Eur J Immunol. 33, 1925-33 (2003)(PMID:12884856)

Flow Cytometry

  1. Legrand F et al. Human eosinophils exert TNF-α and granzyme A-mediated tumoricidal activity toward colon carcinoma cells. J Immunol. 185, 7443-51 (2010)(PMID:21068403)

ELISA

  1. Pitabut N et al. Potential function of granulysin, other related effector molecules and lymphocyte subsets in patients with TB and HIV/TB coinfection. Int J Med Sci. 10, 1003-14 (2013)(PMID:23801887)
  2. Pitabut N et al. Decreased plasma granulysin and increased interferon-gamma concentrations in patients with newly diagnosed and relapsed tuberculosis. Microbiol Immunol. 55, 565-73 (2011)(PMID:21545511)

Other

  1. Lin YC et al. Vancomycin-Induced Stevens-Johnson Syndrome in a Boy Under 2 Years Old: An Early Diagnosis by Granulysin Rapid Test. Front Pediatr. 6, 26 (2018)(PMID:29594082)
Product category
Research area
Apoptosis
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  • The availability is based on the information in Japan at 17:00, Apr 20, 2024 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications：
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.