Background |
M6 is a membrane glycoprotein that is abundantly expressed on central neurons in the CHS. Two distinct murine M6 cDNA (designated M6a and M6b) whose deduced amino acid sequences are remarkably similar to that of the major CNS myelin protein PLP/DM20 are known. PLP expression is limited to the white matter. M6a appears in post-mitotic neurons of the brain and spinal cord as early as embryonic day 10, and later in the hippocampus, cerebral cortex, and the granule cells of the cerebellum. In contrast, M6b is expressed at early embryonic stage in the ventricular zone of the spinal cord, and later during development in both neurons and glia. |
Citations |
Flow Cytometry - Lua I et al. Characterization of hepatic stellate cells, portal fibroblasts, and mesothelial cells in normal and fibrotic livers. J Hepatol. 64, 1137-1146 (2016)(PMID:26806818)
Immunocytochemistry - Aparicio GI et al. Identification of Potential Interacting Proteins With the Extracellular Loops of the Neuronal Glycoprotein M6a by TMT/MS. Front Synaptic Neurosci. 12, 28 (2020)(PMID:32848694)
Immunohistochemistry - Cooper B et al. Glycoprotein M6a is present in glutamatergic axons in adult rat forebrain and cerebellum. Brain Res. 1197, 1-12 (2008)(PMID:18241840)
- Zhao J et al. M6a is expressed in the murine neural retina and regulates neurite extension. Mol Vis. 14, 1623-30 (2008)(PMID:18776950)
- Dorrell C et al. Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers. Mol Cell Endocrinol. 339, 144-50 (2011)(PMID:21539888)
- Lua I et al. Myofibroblastic Conversion and Regeneration of Mesothelial Cells in Peritoneal and Liver Fibrosis. Am J Pathol. 185, 3258-73 (2015)(PMID:26598235)
- Li Y et al. Role of TGF-β signaling in differentiation of mesothelial cells to vitamin A-poor hepatic stellate cells in liver fibrosis. Am J Physiol Gastrointest Liver Physiol. 310, G262-72 (2016)(PMID:26702136)
Immunofluorescence - Cooper B et al. Glycoprotein M6a is present in glutamatergic axons in adult rat forebrain and cerebellum. Brain Res. 1197, 1-12 (2008)(PMID:18241840)
- Monteleone MC et al. Neural glycoprotein M6a is released in extracellular vesicles and modulated by chronic stressors in blood. Sci Rep. 7, 9788 (2017)(PMID:28851962)
Other(magnetic cell separation) - Li Y et al. Role of TGF-β signaling in differentiation of mesothelial cells to vitamin A-poor hepatic stellate cells in liver fibrosis. Am J Physiol Gastrointest Liver Physiol. 310, G262-72 (2016)(PMID:26702136)
Other(Transmission electron microscopy (TEM)) - Monteleone MC et al. Neural glycoprotein M6a is released in extracellular vesicles and modulated by chronic stressors in blood. Sci Rep. 7, 9788 (2017)(PMID:28851962)
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