Code No. D028-5
Anti-CD66c (KOR-SA3544) (Human) mAb-PE
Availability (in Japan)
10 or more
（In Japan at 17:00,
Apr 18, 2024 in JST）
Size
1 mL (50 tests)
Data Sheet| Clonality | Monoclonal | Clone | KOR-SA3544 | ||
|---|---|---|---|---|---|
| Isotype (Immunized Animal) | Mouse IgG1 | ||||
| Applications |
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| Immunogen (Antigen) | cell line (KOCL-22) established from bone marrow blood of patient with congenital leukemia | ||||
| Reactivity [Gene ID] | Human[4680] |
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| Storage buffer | PBS/1% BSA/0.09% NaN3 | ||||
| Storage temp. | 4°C | Conjugate | PE | Manufacturer | MBL |
| Alternative names | CEACAM6, NCA, CEAL | ||||
| Background | This monoclonal antibody (clone KOR-SA3544) was reactive with a surface antigen expressed on Philadelphia chromosome (Ph1)-positive acute lymphoblastic leukemia (ALL) without exception (26/26 cases). The recognized antigen is a nonspecific cross-reacting antigen (NCA)-50/90 (CD66c), one of the carcinoembryonic antigen (CEA)-related glycoproteins encoded by a member of the CEA gene family. The Philadelphia chromosome (Ph1) has been implicated as the causative factor in greater than 90% of chronic myelogenous leukemia (CML), in 25-30% of adult and 2-10% of childhood acute lymphoblastic leukemia (ALL) and in rare cases of acute myelogenous leukemia (AML). The presence of the Ph in leukemic cells of ALL patients usually indicates poor prognosis and high risk. Sequential monitoring of the Ph in ALL correlates with the activity of malignant clones and predicts impending clinical relapse, and therefore is useful in guiding clinical therapeutic decisions. |
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| Related products | D028-3 Anti-CD66c (KOR-SA3544) (Human) mAb D028-4 Anti-CD66c (KOR-SA3544) (Human) mAb-FITC |
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- The availability is based on the information in Japan at 17:00, Apr 18, 2024 in JST.
- The special price is shown in red color.
- Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
- Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation - For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
- For storage temparature: RT: room temparature
- Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.