Anti-p27^Kip1 pAb

Availability (in Japan)

1-9

（In Japan at 17:00,
Apr 19, 2024 in JST）

Size

100 µL

Data	Western Blotting
Clonality	Polyclonal	Clone	Polyclonal
Isotype (Immunized Animal)	Rabbit Ig (aff.)
Applications	WB 1:100-1:1,000 IP 5 μL/100 μL of cell extract from 5x10⁶ cells FCM 1:100 (final concentration) IC 1:100
Immunogen (Antigen)	Recombinant Mouse p27^kip1
Reactivity [Gene ID]	Human[1027], Mouse[12576]
Storage buffer	PBS/50% glycerol, pH 7.2
Storage temp.	-20°C	Conjugate	Unlabeled	Manufacturer	MBL
Alternative names	CDKN1B
Background	Cyclin dependent kinase inhibitory protein 1 (Kip1) is a 27 kDa inducible inhibitor of cyclin-dependent kinase complexes (CKI). It acts by suppressing S-phase entry and thereby blocking cell cycle progression. Kip1 interacts strongly with D-type cyclins in complex with Cdk4 and weaklier with cyclin E/Cdk2 complex to cause G₁ arrest. Kip1 is a potent tumor suppressor for multiple epithelially derived neoplasias, and expression of Kip1 is frequently down regulated in human tumors. Kip1 levels are regulated by phosphorylation and degradation via the ubiquitin-proteosome pathway.
Product category	Research area Cancer

The availability is based on the information in Japan at 17:00, Apr 19, 2024 in JST.
The special price is shown in red color.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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