Anti-MELK (Human) mAb

Availability (in Japan)

10 or more

（In Japan at 00:05,
Apr 20, 2024 in JST）

Size

100 µL (1 mg/mL)

Citations

Data Sheet

SDS

Data	Western Blotting Immunohistochemistry
Clonality	Monoclonal	Clone	11-28
Isotype (Immunized Animal)	Mouse IgG1 κ
Applications	WB 1 µg/mL IH 1-5 µg/mL (Heat treatment is necessary for paraffin-embedded sections.)
Immunogen (Antigen)	Recombinant protein, corresponding to amino acids 264-601 of human MELK
Reactivity [Gene ID]	Human[9833]
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C	Conjugate	Unlabeled	Manufacturer	MBL
Alternative names	maternal embryonic leucine zipper kinase, hPK38, HPK38, pEg3 kinase
Background	MELK is a member of the AMPK serine/threonine kinase family. It is involved in mammalian embryonic development. Overexpression of MELK protein is also reported in various types of human cancer. MELK plays critical roles not only in cancer cell growth but also in formation or maintenance of cancer stem cells that have the ability to self-renew and differentiate. Emerging evidence indicates that cancer stem cells are resistant to chemotherapy and radiation therapy and are associated with cancer relapse. For these reasons, MELK is considered a promising drug target molecule for cancer treatment.
Citations	Immunohistochemistry Chung S et al. Preclinical evaluation of biomarkers associated with antitumor activity of MELK inhibitor. Oncotarget 7, 18171-82 (2016)(PMID:26918358)
References	Chung S et al. Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer. Oncotarget 3, 1629-40 (2012)（PMID: 23283305）
Product category	Research area Stem cell research Cancer

The availability is based on the information in Japan at 00:05, Apr 20, 2024 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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